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JoeR
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Advantage of cloning?
12/28/06 09:27 PM
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I keep seeing on the news how the USDA has approved clone animals for human consumption.
What is the benefit of cloning over AI? Is it really cost effective for ranchers or dairy farmers to clone? I just can't see the real benefit over the cost. A good breeding program should be almost as effective as cloning, but not sure how it works on large scale agri-business.
Joe
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JazzDad
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Re: Advantage of cloning?
[re: JoeR]
12/29/06 08:11 AM
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Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good. Well, if you get a good one, it will be consistently good.
All kids are gifted; some just open their packages earlier than others.-Michael Carr
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jdc40
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Re: Advantage of cloning?
[re: JoeR]
12/29/06 08:57 AM
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I would think that cloning cost wise would be higher than AI. If you had a "perfect animal" you get that result everytime( in theory) by cloning. When you AI your passing good genes from each parents gene pool, but that doesn't mean that animal will perform on the same level, but it has a good chance. My question is what animals will be considered "perfect to clone" and who will be determining what animal gets cloned. Jerry
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JoeR
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Re: Advantage of cloning?
[re: jdc40]
12/29/06 09:52 AM
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I was taught that reproduction and mixing of the gene pool helped increase resistance to diseases. If you clone an entire herd, then when one gets sick, they all get sick! You could lose the entire herd to some simple bacteria. That's a big risk! I could see somone cloning a prize winning bull, but if you keep using the same gene pool, then the species never improves beyond that.
Joe
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Pat
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Re: Advantage of cloning?
[re: JoeR]
12/29/06 04:01 PM
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jdc and Joe, I don't think the ag industry proponents of cloning are so uninformed as to not have considered everything we have mentioned and more. IF all the factors that they consider, in aggregate do not disuade them from cloning it is probably for good cause (AKA improved bottom line.)
I wonder about the loss of genetic diversity as was mentioned. Diversity is what may let a few animals survive a threat and live to pass on the survival characteristic. I don't know how the cloning would be applied. Maybe as a part of a selective breeding program with plenty of genetic diversity where superior animals are developed and then cloned with only the clones at great risk to a pathogen comprising a "magic bullet."
I am somewhat amazed at all the ignorance in the general population regarding the safety of eating cloned beef or eggs from cloned super hens or milk from cloned super milker cows. The average person on the street probably hasn't a clear understanding of the difference between cloning and transgenetics. I am a lot more worried about transgenetics than clones.
Pat
"I'm not from your planet, monkey boy!"
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aussie
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Re: Advantage of cloning?
[re: Pat]
12/29/06 08:39 PM
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Hi, Pat. Cows, sheep, and most other creatures we are familiar with, including ourselves, produce the occasional set ot twins. Identical twins, I assume, are genetically identical, and we think nothing of eating either or both bovine twins, or either or both twin of any other domesticated species. Why should clones be any different?
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Pat
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Re: Advantage of cloning?
[re: aussie]
12/30/06 11:12 AM
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aussie, I agree that the twins are pretty much equivalent of clones with respect to one another but not with respect to a parent for whatever difference that could make. I agree with you completely, as regards cloned beef should be safe. I would consider it safe unless or until there is some way to show that the genetic code describing the animals formation is altered or damaged somehow in the cloning techique. The theory, on the surface, is certainly not something to cause concern. You just trick the sexual reproduction process to take off with only the genetic info of a single animal not the traditional pair.
There is something to be said for redundancy and the error correcting possibillties when you have two sets of genetic data. There is a higher probability of a genetic error when cloining but I don't think anyone is suggesting cloning the clones of clones. That would be like making a Xerox copy of a Xerox copy of a Xerox copy. Error rrates multiply and soon you would have quite defective animals that might not survive to be born.
My "take" on cloning is to try to find a genetic foundation animal with minimal genetic "shortcomings" so the copy process introduces the least error into the cloned animal. If you start with good genetics and stop at the first generatiion clone I have trouble seeing how eating the clone would be dangerous.
Unfortunately the general public is essentialy ignorant of even the basics of science, at least here in the good old U.S. of A. where creation science (an oxymoron) is considered on equal grounds along side real science.
I think the basic idea of cloning the best of the best to produce the best carcass traits in commercial slaughter is sound and will eventually reduce the risk of getting a "bad" cut of meat, too tough to enjoy.
I almost forgot... You asked, "Why should clones be any different?"
Twins are identical copies (give or take mionor errors) of each other. Two animals made from the same recipe so pretty similar results. They are however, made from two different sets of genetic codes (one set from each parent) and the redundancy helps correct for errors.
On the other hand clones have two copies of the same identical genetic codes so there is no redundancy as with twins (or single births through normal means.) This introduces risk precisely because there is no redundancy, no way for errors to be detected or correncted. This will increase the number of genetic deficiencies which will be and are expressed in vaious deformaties, not only visible deformaties, but various problems at the lowest levels of synthesis in the chemical processes in the animals body. If you code incorrectly for a particular protein or whatever you might get a sheep that looks like mom but dies at an early age because it just "wasn't right." Remember Dolly?
I don't claim this makes the meat poison but I am not an expert and will defer to proper science to take a whack at the issue before I run to the supermarket to stock up on SUPER BEEF.
Pat
"I'm not from your planet, monkey boy!"
Edited by Pat (12/30/06 11:24 AM)
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egon
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Re: Advantage of cloning?
[re: Pat]
12/30/06 03:47 PM
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I'm all for "Cloning". Can you imagine a world full of worker "Egons"?
Durable backs, mild, even temperment, easily led, and all with a bulb of sufficient wattage to be productive yet not create problems! IE- Dim bulb!
Egon
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aussie
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Re: Advantage of cloning?
[re: Pat]
12/31/06 03:18 AM
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There is no shortage of Creationism or Intelligent Design down here, Pat, although most of it's advocates come from USA based religions (thank you so much ).Your reply made very interesting reading and helped clear up some of the areas not covered in the Media. What about plants grown from cuttings? Are they considered to be cloned? I am thinking about food plants here, of course..
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Pat
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Re: Advantage of cloning?
[re: egon]
12/31/06 01:45 PM
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Egon, I wish I could clone myself and get a late teen or early adult real fast. Maybe better 4-7 of them. Maybe I could get some more of my projects done in a realistic time frame. I wiold need to adjust the personality profile in a few ways to ensure desireable results.
HMMMM< recall the comedy movie, "Multiplicity?"
Pat
"I'm not from your planet, monkey boy!"
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Pat
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Re: Advantage of cloning?
[re: aussie]
12/31/06 02:30 PM
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aussie, I don't think cuttings to grow a plant is cloning. Just like grafting is not cloning. Cloning is when you take a plant cell and stimulate and or manipulate it such that it begins to replicate and produce tissue and ideally a new plant.
Back in the 60's the primitive approaches to cloning, trying to grow a plant from a single cell of a "parent" (or donor plant) often resulted in some sort of lump of tissue and not a viable plant. We've come a long way baby!
Intelligent Design: I strongly believe in intelligent design. I also strongly believe that evolutiion IS intellligent design!!
Pat
"I'm not from your planet, monkey boy!"
Edited by Pat (12/31/06 02:32 PM)
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egon
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Re: Advantage of cloning?
[re: Pat]
12/31/06 03:46 PM
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Macintosh apples, the kink you eat are all from the same original tree.
Egon
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Pat
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Re: Advantage of cloning?
[re: egon]
01/01/07 08:52 AM
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Egon, Sounds, well, Kinky!
Grapes are propagated through cuttings which also IS NOT cloning but you end up with an entire vineyard that is populated with the EXACT same plants which will produce the exact same grapes. Wonderful stuff until something comes along that can cause that plant a problem and then the whole vineyard is in danger. Ahh, the pros and cons of biodiversity.
Trivia question of the day: A navel (belly button) is the point where the offspring is connected to the mother by an umbilicus. If some sort of cloning such as is often depicted in Sci Fi were actually able to successfully grow a human would you be able to easily ID them at the beach due to their lack of a belly button?
Pat
"I'm not from your planet, monkey boy!"
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egon
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Re: Advantage of cloning?
[re: Pat]
01/01/07 09:31 AM
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Plastic surgery.
Egon
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Pat
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Re: Advantage of cloning?
[re: egon]
01/01/07 12:56 PM
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Egon, A favorite line from the Dustin Hoffman movie, "The Graduate."
"...just one word, plastic."
Oh, plastic surgery. Yes, but to give a clone an ersatz navel or to elliminate someone's natural navel for the smooth unblimished look?
Imagine the Sports Illustrated swim suit edition with no navels.
Off topic comment: Just finished watching the Rose Parade and the taped replay. I think Oklahoma made quite a splash. I liked the all too short exposure of the B-2 escourted by the two Raptors (F-22) but that spectacular moment was totally eclipsed when the gift wrapped box on the Oklahoma float opened up and like a child's jack-in-the-box springing up, out came THE ROCKET MAN wearing his rocket pack who then took off and flew down the parade route to a near perfect landing.
Pat
"I'm not from your planet, monkey boy!"
Edited by Pat (01/01/07 01:00 PM)
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egon
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Re: Advantage of cloning?
[re: Pat]
01/01/07 01:10 PM
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I have never seen the swimsuit edition. Heard about it though.
Our TV has not been activated today. Stoking the fire, a comfortable black chair, view of the bird feeder and a book by Dale Brown about exotic aircraft and satellite systems have taken up almost all my time.
Egon
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Pat
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Re: Advantage of cloning?
[re: egon]
01/01/07 01:35 PM
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Egon, I think it is pretty funny that the stuff that I was exposed to that required permanently abridging my rights under the constitution is now openly published in Jane's and other pubs like the one you are reading on satellites. Overhead assets, wonderful stuff. I can neither confirm nor deny the existance of certain satellites much less their capabilities even though some of my digraphs are quite suggestive. This after the stuff is in news papers, magazines, and movies.
The theory being that somewhere there just may still be someone who doesn't know for sure the exact parameters and confirming or denying any attributes or figures of merit would allow someone to reverese engineer the performance capability.
Meanwhile, it makes for interesting reading for a fan such as yourself.
Pat
"I'm not from your planet, monkey boy!"
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jdc40
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Re: Advantage of cloning?
[re: Pat]
01/02/07 09:53 AM
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Pat, I have a "what if" question. If everthing is kept in balance due to the process of evolution and we start cloning on a large basis will that effect evolution, and if so what happens when everything cloned is attacked by some disease. I know that cloning isn't meant for cloning the elk, bear, whitetail, bass, trout and so on, but that is "what if".
Hope everybody had a Happy New Year, jerry
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Pat
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Re: Advantage of cloning?
[re: jdc40]
01/02/07 11:21 AM
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Jerry, You sure got an early start this year and didn't waste time on starting with the easy questions. Wow!
OK, lets see... I guess we need to handle this multi-parter one small chunk at a time. You start out with a GIANT IF. IF everything is kept in ballance by evolution... WHOAA!! I don't think so. Is everything kept in ballance by evolution? I don't understand your position on that. I thought it was pretty obvious that evolution improves or at least creates changes to better match environmental challenges/pressures through natural selection. Evolution is reactive not proactive. Evolution doesn't purposefully create and nurture a branch in anyone's family tree so that in case X happens there will be individuals better able to cope with X and survive.
Take the classic example of the giraffe. If there had been enough "short" food for everyone then a mutation or even an individual at the extreme edge of the envelope with respect to neck length might have not had a survival advantage and the giraffe would have not evolved a long neck.
Mow to the general question, "will large scale cloning effect evolution?" Well yes, I believe so but in a minor way. If a large percentage of the animals on the earth are clones then fewer animals are available to participate in evolution and as often repeated, a single problem successfully targeting a population could wipe it out due to the lack of diversity.
Simply stated evolution goes like this... In any large population of a species there are individual differences. Sometimes there are mutations that present larger that typical individual differences. These individuals compete in their environment (environment, meaning ALL their extant conditions not just weather) and some are better suited to survive and pass on their genes. Pressure can be exerted on the survivability of an individual or whole species by changes in their environment. These changes could be the arrival of a competing species that eats all the low food which rewards taller individuals with proportionally more food. The taller will be more succesful at raising young due to more abundant food supply and will pass on their genes. Lets say the taller than normal neck was a mutation. These mutated genes will be passed on better than the genes of the short neck kin who are starving due to competition for low food.
Individuals with mutant genes are often misfits and are not suerior competitors for food, habitat, or whatever but sometimes a mutant gene can cause a change that gives a competitive advantage in some respect and then it will be passed on. Mutatioins can be responsible for "leaps" in evolution. Otheriwise evolution can be rather slow. There are lots of minor variations in the intricate chemical processes of coding for various substances in a complex organism like a mamal. Some of the variants have superior survival value as regards some survival issue and some are negative or not particularly involved.
Take the evolution of milk drinkers for instance. Northern Europeans were heavier into milking cows for food than most folks, especially black Africans (except for notible exceptions like the Masai tribe. There was a distribution of ages where a person could digest milk. Milk contains milk sugar, lactose, which is broken down by the enzyme lactase which most folks produce sufficiently so they can nurse their mothers and survive. There is no survival value to producing the lactase enzyme very far past weening age UNLESS milk is a valuable portion of your diet. In populations were milk drinking as an adult is not popoular there is no survival value to an adult's production of lactase to enable lastose digestion.
Northern Europeans (and certain others) relied on milk as adult food and the individuals who could digest it had a better chance of survival so over time they evolved, in the main, to be able to digest milk into old age. Most black Africans can't digest milk. The Masai sell milk products at market to other tribes but only in the forms of cheese and yogurt where the milk sugar has been chemically processed by bacteria.
I loved milk and drank huge quantities as a lad but am now lactose intollerant (since about 25 years of age or so) and have to take a lactase supplement if I want to drink milk. You can buy pretreated milk too. So, I was marginalized by the evolutionary process and had it not been for food science industry producing lactase enzyme pills I wouild have not been able to use milk as a food.
Since evolution uses natural selection to better fit the breed to the environment and since clones are not likely to be used extensively for breeding they are sort of out of it, standing to one side and not involved in evolution. Why make clones in order to breed them? The case of the "Prize Bull" sounds attractive on the surface but the bull would have a higher probabability of having genetic defects in its sperm than the animal from whch it was cloned. AI sounds like a beter investment for producing a herd bull than cloning. Cloning may become the method of choice for end user consumption with only single generation cloning.
I'm sure the cloninig researchers and their money sources have their eyes way over the horizon that stops youi and I from seeing what all they are hoping for. I'm sure I am way underinformed about the hopes and aspirations of cloners. Who knows maybe one day we can clone body parts specificly for an individual and not have rejection problems. How about a new young strong heart for an aged heart patient tht is essentially HIS heart, just newer?
I'm sorry for all the misspellings. Big fingers, haste, and an overabundance of fresh large dark floaters are only some of my excuses. I'll try to be a better netizen (not misspelled) next time.
Pat
"I'm not from your planet, monkey boy!"
Edited by Pat (01/02/07 04:07 PM)
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jdc40
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Re: Advantage of cloning?
[re: Pat]
01/03/07 03:28 PM
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Pat, I thought Darwin attributed the world to natural selection(the theory of evolution) and that evolution is a process of "descent of modification", that all living things are related to one another in a common tree of descent. So I guess I was trying to say that when things are in "balance", like the food chain all things keep everything balanced but if you remove say the grass then it throws everything out of "balance".
So I in someways think that evolution helps keep things in balance, because of it allowing diversity. It was a "what if" say we used cloning to help save what we have destroyed in tigers, rhinos, elephants, and so forth. I sure I'm not totally correct in my thinking and also not well informed.
So it is highly unlikely that cloning would take over as a method of reproducing or repopulating a certain species. Sorry for being difficult. Jerry
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Pat
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Re: Advantage of cloning?
[re: jdc40]
01/04/07 03:15 PM
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Jerry, No problem, It is good to have to exercise the little grey cells as my favorite Belgian detective always said.
Cloning, if not way improved over the current state of the art, would not really save an endangered species but would introduce and or amplify genetic problems into the population (Xerox copy of a Xerox copy problem... with increasing entropy or "noise.") IF you wanted tiger looking things to put in a zoo then clones that are viable health wise woulld fill the bill but not make good mating partners for preserving the species.
Cloning of indigvidual organs would be a boon to mankind and could perhaps save rhinos. tigers and such animals as as are slaughtered to make hilts for decorative daggers for Arabs or are ground up to make phony "medicines" and aphrodisiacs. You could clone rhino horn and tiger parts and such for the market place to take the pressure off the animals through poaching.
Pat
"I'm not from your planet, monkey boy!"
Edited by Pat (01/04/07 03:19 PM)
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lovethesticks
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Re: Advantage of cloning?
[re: egon]
01/05/07 09:53 PM
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Yes MacIntoshs are all from the same original tree. But one grown in Michigan does not taste the same as one grown in Connecticut. I loved eating Gravenstein apples in Washington State, but the ones grown in Michigan lack the flavor, "bite" and size of the ones in Washington. Would a clone be a clone if raised in a different environment? I'll let the intelligent people sort that one out. Chris
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Pat
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Yet more evidence brought to bear in the "NATURE" vs "NURTURE" debate! The environment in the widest sense of he word makes the difference. The weather, climate, soil, and all factors involving the health and welfare of the tree have a potential effect on the fruit.
The genetics of the cuttings used for grafting are a pattern, a set of instructions of how to assemble the available ingredients into a tree and its fruit and there are many factors that have influence over the final resultant fruit.
The good news is that by grafting you are actually getting a tree that is a part of the original tree, not a daughter tree but an actual part of the original tree. There are no introduced genetic differences or errors like you could get by planting seeds produced by the original tree. All those trees are actually just widely separated pieces of the same tree. This gets arouind the Xerox copy of a Xerox copy problem for the most part. YOu can still have replicative mutations when new cells are formed but this is a lower order source of defect as compared to cloning.
Now if you want to talk about risk... If some disease comes along that is really bad news for one of the trees it is potentially a real killer for any/all of the trees that are exposed.
Pat
"I'm not from your planet, monkey boy!"
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